3.3 Difference of CD161+CD56+NK cells proportion in pSS patients with different clinical manifestations
We compared the differences of CD161+CD56+NK cells proportion in pSS
patients with different clinical manifestations(Table 2), it was found that the
proportion of CD161+CD56+NK cells with decayed tooth(53.60%±16.83% vs.
67.00%±9.81%,P =0.013,Fig.2A) ,fatigue(55.71%±17.50% vs. 67.54%±10.49%,P =0.030,Fig.2B), arthralgia(57.38%±14.24%vs.69.69%±12.04%,P =0.030,Fig.2C), skininvolvement(49.84%±18.09%vs.66.30%±11.94%,P =0.016,Fig.2D), PBC(49.00%±
21.32%vs.66.31%±12.64%,P =0.028,Fig.2E) and ILD(53.32%±17.57% vs.67.78%±10.23%,P =0.008,Fig.2F) in pSS patients notably decreased compared with pSS
patients without above manifestations.
We also analyzed the difference in the proportion of CD161+CD56+NK
cells between pSS patients with positive and negative autoantibodies.The resultsshowed that the proportion of CD161+CD56+NK cells in patients with Anti-
SSA/Ro60 positive(59.59%±15.25% vs.76.34%±13.47%,P =0.021,Fig.2G) and
Anti-SSB positive (57.96%±15.63% vs.74.76%±11.06%,P =0.005,Fig.2H) was
significantly lower than that in patients with negative autoantibodies.Compared
with pSS patients with normal IgG, the proportion of CD161+CD56+NK cells inpatients with high IgG obviously decreased(57.22%±15.95% vs.70.85%±10.87%,P =0.018,Fig.2I).However, there was no significant difference in the proportion of CD161+CD56+NK cells between pSS patients with dry mouth, dry eye,
gland involvement, leukopenia and raynaud’s phenomenon and patients without
the above clinical manifestations.The proportion of CD161+CD56+NK cells
only slightly decreased in anti-SSA/Ro52 positive and anti-centromere positive patients compared with anti-SSA/Ro52 and anti-centromere negative patients,
but there was also no statistical difference.