2.2 Data Collection
We recorded the detailed clinical manifestations of these pSS patients, such as dry mouth, dry eye, decayed tooth, fatigue, arthralgia, raynaud’s phenomenon, skin involvement, gland involvement, fever, muscle involvement, renal tubular acidosis, interstitial lung disease(ILD) and primary biliary cirrhosis(PBC) etc.At the same time, the laboratory data such as white blood cell count, red blood cell count, platelet count, erythrocyte sedimentation rate (ESR), C- reactive protein (CRP), rheumatoid factor (RF), serum globulin, immunoglobulin(IgG,IgA,IgM),complement (C3,C4) and autoantibodies(anti-SSA/Ro52, anti-SSA/Ro60, anti-SSB/La and anti-centromere) were collected.The blood samples for above tests were fasting blood from pSS patients in the morning.According to the above clinical manifestations and laboratory parameters, the European League Against Rheumatism Sjogren’s Syndrome Disease Activity Index(ESSDAI) and European League Against Rheumatism Sjogren’s Syndrome Patient Reported(ESSPRI) of patients were evaluated[14].ESSPRI is the patient’s subjective score, which is the average of the three points including dryness, pain and fatigue, and each evaluation score range is 0 to 10. ESSDAI is the pSS disease activity index, which is calculated according to patients’s clinical manifestations, laboratory parameters, and corresponding weight coefficient.At the same time,general informations of HCs such as gender and age were collected.