5.Conclusion
In conclusion, in this study, we revealed that the proportion of CD56+NK
cells and CD161 on CD56+NK cells in peripheral blood of pSS patients
significantly decreased compared to HCs. The proportion of CD161+CD56+NK
cells was significantly correlated with the clinical features and
laboratory parameters including autoantibodies and immunoglobulins in
pSS patients, and negatively associated with disease activity and
severity of pSS. The ROC curve showed that CD161+CD56+NK cells had
certain reference value for the diagnosis of pSS.In short, our findings
suggest that CD161+CD56+ NK cells may influence the progression of pSS
and serve as a biomarker of disease activity and potential targets for
therapy of pSS.
Fundings: The study was funded by Science and Technology
Programme of Suzhou(SLJ2021009), Natural Science Key Project of Bengbu
Medical College (2022byzd070),Gusu Talent Project of Suzhou
(GSWS2020011,GSWS2020018),Science and Technology Programme of
Suzhou (SKY2023138).