2.2 Data Collection
We recorded the detailed clinical manifestations of these pSS patients,
such as dry mouth, dry eye, decayed tooth, fatigue, arthralgia,
raynaud’s phenomenon, skin involvement, gland involvement, fever, muscle
involvement, renal tubular acidosis, interstitial lung disease(ILD) and
primary biliary cirrhosis(PBC) etc.At the same time, the laboratory data
such as white blood cell count, red blood cell count, platelet count,
erythrocyte sedimentation rate (ESR), C- reactive protein (CRP),
rheumatoid factor (RF), serum globulin,
immunoglobulin(IgG,IgA,IgM),complement (C3,C4) and
autoantibodies(anti-SSA/Ro52, anti-SSA/Ro60, anti-SSB/La and
anti-centromere) were collected.The blood samples for above tests were
fasting blood from pSS patients in the morning.According to the above
clinical manifestations and laboratory parameters, the European League
Against Rheumatism Sjogren’s Syndrome Disease Activity Index(ESSDAI) and
European League Against Rheumatism Sjogren’s Syndrome Patient
Reported(ESSPRI) of patients were
evaluated[14].ESSPRI is the patient’s subjective
score, which is the average of the three points including dryness, pain
and fatigue, and each evaluation score range is 0 to 10. ESSDAI is the
pSS disease activity index, which is calculated according to patients’s
clinical manifestations, laboratory parameters, and corresponding weight
coefficient.At the same time,general informations of HCs such as gender
and age were collected.