5.Conclusion
In conclusion, in this study, we revealed that the proportion of CD56+NK cells and CD161 on CD56+NK cells in peripheral blood of pSS patients significantly decreased compared to HCs. The proportion of CD161+CD56+NK cells was significantly correlated with the clinical features and laboratory parameters including autoantibodies and immunoglobulins in pSS patients, and negatively associated with disease activity and severity of pSS. The ROC curve showed that CD161+CD56+NK cells had certain reference value for the diagnosis of pSS.In short, our findings suggest that CD161+CD56+ NK cells may influence the progression of pSS and serve as a biomarker of disease activity and potential targets for therapy of pSS.
Fundings: The study was funded by Science and Technology Programme of Suzhou(SLJ2021009), Natural Science Key Project of Bengbu Medical College (2022byzd070),Gusu Talent Project of Suzhou (GSWS2020011,GSWS2020018),Science and Technology Programme of
Suzhou (SKY2023138).