3.3 Difference of CD161+CD56+NK cells proportion in pSS patients
with different clinical manifestations
We compared the differences of CD161+CD56+NK cells proportion in pSS
patients with different clinical manifestations(Table 2), it was found
that the
proportion of CD161+CD56+NK cells with decayed tooth(53.60%±16.83% vs.
67.00%±9.81%,P =0.013,Fig.2A) ,fatigue(55.71%±17.50% vs.
67.54%±10.49%,P =0.030,Fig.2B),
arthralgia(57.38%±14.24%vs.69.69%±12.04%,P =0.030,Fig.2C),
skininvolvement(49.84%±18.09%vs.66.30%±11.94%,P =0.016,Fig.2D),
PBC(49.00%±
21.32%vs.66.31%±12.64%,P =0.028,Fig.2E) and ILD(53.32%±17.57%
vs.67.78%±10.23%,P =0.008,Fig.2F) in pSS patients notably
decreased compared with pSS
patients without above manifestations.
We also analyzed the difference in the proportion of CD161+CD56+NK
cells between pSS patients with positive and negative autoantibodies.The
resultsshowed that the proportion of CD161+CD56+NK cells in patients
with Anti-
SSA/Ro60 positive(59.59%±15.25%
vs.76.34%±13.47%,P =0.021,Fig.2G) and
Anti-SSB positive (57.96%±15.63%
vs.74.76%±11.06%,P =0.005,Fig.2H) was
significantly lower than that in patients with negative
autoantibodies.Compared
with pSS patients with normal IgG, the proportion of CD161+CD56+NK cells
inpatients with high IgG obviously decreased(57.22%±15.95%
vs.70.85%±10.87%,P =0.018,Fig.2I).However, there was no
significant difference in the proportion of CD161+CD56+NK cells between
pSS patients with dry mouth, dry eye,
gland involvement, leukopenia and raynaud’s phenomenon and patients
without
the above clinical manifestations.The proportion of CD161+CD56+NK cells
only slightly decreased in anti-SSA/Ro52 positive and anti-centromere
positive patients compared with anti-SSA/Ro52 and anti-centromere
negative patients,
but there was also no statistical difference.