3.2 The proportion of CD56+NK cells and CD161+CD56+NK cells decreased in pSS patients
In order to evaluate the expression of CD56+NK cells and CD161 on surface of CD56+NK cells in peripheral blood of pSS patients and HCs,we used flow cytometry to detect the proportion of CD56+NK cells and CD161+CD56+NK cells.The results showed that the proportion of CD56+NK cells decreased markedly compared with HCs(9.16%(3.05%-21.80%)vs.12.75%(7.36%-26.40%),P =0.0052)(Fig.1C). Similarly, the proportion of CD161+CD56+NK cells was also significantly lower than that in HCs (65.90% (25.15%-96.10%) vs. 76.10% (5.22%-96.40%), P =0.0013)(Fig.1D).The gating strategies for CD56+NK cells and CD161+CD56+NK cells are represented in Fig.1A,and the representative FACS plots are shown in Fig.1B.