Effect of HCG-triggered ovulation on pregnancy outcomes in intrauterine
insemination: an analysis of 5610 first IUI natural cycles with donor
sperm in China
Objective: To evaluate the effect of human chorionic gonadotropin (hCG)
trigger ovulation on pregnancy outcomes in natural IUI cycles with donor
sperm. Design: Retrospective cohort study. Setting: Not applicable.
Patients: A total 5610 first-natural IUI cycles with donor sperm in
infertile couples during the period from January 2012 to December 2017.
To control for other confounding factors, our analysis was restricted to
normo-ovulatory women without tubal infertility. Intervention(s):
hCG-triggered ovulation Main Outcome Measures: The main outcome measure
was live birth rate; the secondary outcomes included rates of clinical
pregnancy and miscarriage. Results: In the crude analysis, both the
clinical pregnancy (27.40% versus 22.73%; P =0.001) and live birth
rates (24.52% versus 20.13%; P =0.007) were significantly higher for
the hCG group than for the spontaneous LH group. After adjustment for a
number of confounding factors, the reproductive outcomes were still
significantly worse for the spontaneous ovulatory group. Conclusions:
Among women undergoing natural cycle IUI with donor sperm, hCG triggered
ovulation for timing insemination offers beneficial impacts on both
clinical pregnancy rates and live birth rates.