loading page

A physical psychological factor in immunostimulation activity and homeostasis safeguarding
  • Nafissa TELAILIA,
  • Hacène FRIH
Nafissa TELAILIA
Université Badji Mokhtar Annaba Faculté des Sciences
Author Profile
Hacène FRIH
Université Badji Mokhtar Annaba Faculté des Sciences
Author Profile

Abstract

Abstract The objective of our study is to propose a therapeutic strategy based on the administration of cyclosporine alone, and cyclosporine associated with a sound noise in two batches of animals treated with an immunostimulant Biliated bacillus of Calmette and Guerin, all based on the hypothesis of the central role of neuroimmuno-endocrine regulation loop in disorders related to the administration of cyclosporine. We administered cyclosporine alone (IP) for 8 days, as well as administration of cyclosporine associated with sound noise with food and sugar water and stained in two batches of Biliated bacillus of Calmette and Guerin -treated animals ( in ID), the animals received Biliated bacillus of Calmette and Guerin injections on the 9th day and a reminder on the 27th day. Our results show that intraperitoneal injection of cyclosporine alone (20 mg / kg) causes a significant decrease in testosteronemia associated with a drop in body weight. Similar results were found following administration of cyclosporine associated with sound noise. Conversely, administration of cyclosporine alone and associated with sound noise caused a significant increase in adrenocorticotropic hormone. Indicating that sound noise mimics the effect of cyclosporine in male rats. Keywords: Immunosuppression, immunostimulation, psychotherapy, homeostasis