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The Effect of I131 Treatment on Pregnancy Outcomes after Thyroidectomy in Patients with Differentiated Thyroid Carcinoma: A Meta-Analysis
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  • Lijuan Zhang,
  • Yinqiong Huang,
  • Yuanyuan Zheng,
  • Liangchun Cai,
  • Junping Wen,
  • Gang Chen
Lijuan Zhang
Fujian Medical University
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Yinqiong Huang
Fujian Medical University
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Yuanyuan Zheng
Fujian Medical University
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Liangchun Cai
Fujian Medical University
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Junping Wen
Fujian Medical University
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Gang Chen
Fujian Medical University
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Abstract

Objectives: This meta-analysis aims to investigate the association between I131 treatment and pregnancy outcomes. Methods: Electronic database PubMed, Embase and the Cochrane Library were throughly searched until December 2017. Databases were searched for studies that reported the incidence of pregnancy outcomes (spontaneous abortion, induce abortion, premature birth, stillbirth) in DTC participants with I131 treatment or not. Meta-analysis was performed in Stata/SE12. A random or fixed effects model was adopted according to the result of heterogeneity test. Results: A total of 6 observational studies were eligible, involving 14132 participants and 2969 pregnancies. It showed that postoperative I131 treatment for DTC had no significant effect on spontaneous abortion (OR = 1.05, P = 0.701), induced abortion (OR = 1.06, P = 0.859), abortion (OR = 1.07, P = 0.597), premature birth (OR = 1.49, P = 0.073) and stillbirth (OR = 1.58, P = 0.364). The group in which interval time between last I131 treatment and pregnancy >1 year had significantly lower risk of abortion than with interval <1 year (OR = 0.50, P = 0.000. Conclusions: I131 treatment for DTC had no significant effect on pregnancy outcomes. Pregnancy is not recommended for DTC patients within 1 year after 131I treatment.