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Mimicking skin: healthy and disease models for transdermal permeation studies
  • Tânia Moniz,
  • Sofia Lima,
  • Salette Reis
Tânia Moniz
REQUIMTE LAQV Porto
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Sofia Lima
REQUIMTE LAQV Porto
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Salette Reis
REQUIMTE LAQV Porto
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Abstract

Skin drug delivery is an emerging route in the drug development, due to its great advantages, thus leading to an urgent need to understand the behaviour of active pharmaceutical ingredients into/through the skin. This knowledge is crucial in the early stages of product design and development. Yet, given the skin barrier properties as one of the first body’s natural defence systems, it can act as an obstacle to the successful outcome of a skin drug therapy. To unravel the mechanisms underlying this barrier, reductionist strategies have designed several models with different levels of complexity and integrity, using non-biological and biological components. Besides the detail of information and resemblance to the in vivo Human skin that each in vitro model offers, the technical and economic efforts required should be considered when selecting the most adequate model for the intended research. This review provides an outline of the most commonly applied skin models, including healthy and diseased conditions, lab developed systems and commercialized models, their advantages and limitations and, also an overview of the new trends in skin engineered models.

Peer review status:ACCEPTED

19 Mar 2020Submitted to British Journal of Pharmacology
20 Mar 2020Submission Checks Completed
20 Mar 2020Assigned to Editor
22 Mar 2020Reviewer(s) Assigned
24 Apr 2020Editorial Decision: Revise Minor
19 May 20201st Revision Received
21 May 2020Assigned to Editor
21 May 2020Submission Checks Completed
21 May 2020Reviewer(s) Assigned
04 Jun 2020Editorial Decision: Revise Minor
06 Jun 20202nd Revision Received
08 Jun 2020Submission Checks Completed
08 Jun 2020Assigned to Editor
09 Jun 2020Reviewer(s) Assigned
10 Jun 2020Editorial Decision: Revise Minor
15 Jun 20203rd Revision Received
18 Jun 2020Submission Checks Completed
18 Jun 2020Assigned to Editor
18 Jun 2020Review(s) Completed, Editorial Evaluation Pending
18 Jun 2020Editorial Decision: Accept