From the date of unravelling the sequence of pandemic phenomena causing
novel coronavirus (named SARS-CoV-2/COVID-19), there have been limited
but key molecular and structural advancements made a great impact in
COVID 19 research and in the development of therapeutics in a right
direction. The solving the structure of SARS-CoV-2 spike glycoprotein
and its interactions with ACE2/CD26 are the two major findings were
proposing the possible mode of SARS-CoV-2 entry into the host cell.
Following unravelling the camouflaging glycan shied novel incorporation
of Furin cleavage site underlines the district features of a novel
coronavirus from the previous. Taking these key molecular and structural
advancements, we developed the structural model of the SARS-CoV-2
interacting with human host proteins for adhesion and virulence for easy
and scientific understanding for the general reader.