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Molecular and Structural Advancements in SARS-CoV-2 and host interactions
  • Naveen Vankadari
Naveen Vankadari
Monash University, Monash University
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Abstract

From the date of unravelling the sequence of pandemic phenomena causing novel coronavirus (named SARS-CoV-2/COVID-19), there have been limited but key molecular and structural advancements made a great impact in COVID 19 research and in the development of therapeutics in a right direction. The solving the structure of SARS-CoV-2 spike glycoprotein and its interactions with ACE2/CD26 are the two major findings were proposing the possible mode of SARS-CoV-2 entry into the host cell. Following unravelling the camouflaging glycan shied novel incorporation of Furin cleavage site underlines the district features of a novel coronavirus from the previous. Taking these key molecular and structural advancements, we developed the structural model of the SARS-CoV-2 interacting with human host proteins for adhesion and virulence for easy and scientific understanding for the general reader.