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Effect of Intraoperative Oxytocin Infusion on Reducing the Absorption Rate of Irrigation Fluid during Hysteroscopic Myomectomy: A Novel Approach;A clinical Trial
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  • simin Atashkhoyi,
  • leila kafshdouz,
  • hesam Rasoul Amini,
  • Hojjat pourfathi
simin Atashkhoyi
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leila kafshdouz
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hesam Rasoul Amini
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Hojjat pourfathi
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Abstract

Introduction: Uterine leiomyoma is one of the most common benign tumors in women. Severe bleeding and unstable hemodynamics might occur in patients undergoing hysteroscopic myomectomy due to excessive irrigation fluid absorption.The aim of this study was to evaluate the effect of Intraoperative oxytocin infusion on the absorption of irrigation fluid in patients undergoing hysteroscopic myomectomy. Methods: In a randomized double-blind clinical trial, 50 patients aged 25-45 years with American Society of Anesthesiologists (ASA) class I or II undergoing hysteroscopic myomectomy were studied. In the study group (Group O), 250 mL ringer solution containing 15 units of oxytocin was infused at rate of 125 mL/h; while, the placebo group (Group P) received 250 mL ringer solution containing 1.5 ml of normal saline was infused at rate of 125 mL/h.Intraoperative hemodynamic alterations, fluid deficit, declined hemoglobin, hematocrit, sodium and albumin levels from baseline, complications and incidence of toxicity with the administered solutions were evaluated at both intraoperative and 24 hours postoperative phases. Results: The volume of irrigation fluid (P=0.032) and volume deficit (P=0.034) were significantly lower in the Group O. The incidence of intraoperative hypotension was significantly lower in Group O compared to Group P (P=0.019). Serum hematocrit (P=0.043) and sodium (P=0.026) levels were significantly lower in Group O. Conclusion: Intraoperative infusion of oxytocin during hysteroscopic myomectomy might be associated with decreased irrigation fluid absorption and its associated complications. Therefore, this method could be used to reduce the complications caused by the absorption of large volumes of irrigation fluid during hysteroscopic myomectomy