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Respiratory infections regulated blood cells IFN-beta-PD-L1 pathway in pediatric asthma
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  • Julia Koelle,
  • Patricia Haag,
  • Tytti Vuorinen,
  • Alexander Kiefer,
  • Manfred Rauh,
  • Theodor Zimmermann,
  • Nikolaos Papadopoulos,
  • Susetta Finotto
Julia Koelle
mOLECULAR pNEUMOLOGY
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Patricia Haag
Uniklinikum Erlangen
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Tytti Vuorinen
University of Turku
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Alexander Kiefer
Uniklinikum Erlangen
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Manfred Rauh
Uniklinikum Erlangen
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Theodor Zimmermann
Uniklinikum Erlangen
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Nikolaos Papadopoulos
University of Manchester, University of Manchester
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Susetta Finotto
mOLECULAR pNEUMOLOGY
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Abstract

Respiratory infections in general and rhinovirus (RV) infection specifically are the main reason for asthma exacerbation in children. Here we found increased level of Programmed cell death protein 1 ligand (PD-L1) mRNA in total blood cells isolated from pre-school children with virus-induced asthma, with lower FEV1% and with high serum levels of the C-Reactive-Protein (CRP). These data indicate that, in the presence of infection in the airways of preschool children, worse asthma is associated with induced PD-L1 mRNA expression. Further, the activation of regulatory elements that induce IFNβ, a cytokine that is involved in immunity of infections, was found to be associated with better lung function in asthmatic children. Finally, IFN-beta released by peripheral blood Mononuclear cells (PBMC) was found associated with an induced expression of PD-L1mRNA in control but no asthmatic children. These data suggest that improving peripheral blood IFN type I expression in PBMCs in pediatric asthma could improve disease exacerbation because suppressing PDL1 expression in blood cells.