Prognostic factors of IVF&ICSI cycle cancellation in patients with
endometriosis related infertility; A Retrospective Study.
Objective: To elucidate the prognostic factor for IVF&ICSI cycle
cancellation in patients with endometriosis related infertility Design
& Setting The study was a retrospective cohort study and conducted at
Uludag University School of Medicine, ART center, between the years
2011-2017. Population Electronic database were screened and infertile
patients with endometriosis, patients without male factor, systemic
disease, undefined adnexal mass and aged <40 yrs were
selected. Cycles were divided in two groups. (Cancelled vs. Embryo
transferred) Results 44 cycles were cancelled and in 178 cycles embryo
was able to transferred. When the groups were compared Age, day3 FSH
were statically higher and AMH, AFC were statically lower in cycle
cancelled (CC) group. Presence of adenomyosis was higher in CC group.
(64% vs. 40% p<0.01) Surgery rate with laparotomy was higher
in CC group. (54.5% vs. 13.5% p<0.01) AFC (OR:0.81,
CI:0.70:0.93) remained as only independent factor associated with
prognoses of IVF cycle with binary logistic regression analysis.
Cancellation rates were similar between the phenotypes of endometriosis.
Conclusions: Poor ovarian reserve, advanced age, presence of adenomyosis
and the history of laparotomy are negative prognostic factors associated
with IVF&ICSI cycle cancellation in endometriosis related infertility.
AFC is the only independent factor to predict cycle cancellation.
Phenotype of endometriosis does not affect the results. There is no
funding in this study. Key Words: Endometriosis, Infertility,
Adenomyosis, Intracytoplasmic Sperm Injections,