Do the Neutrophil/Lymphocyte ratio and the Platelet/Lymphocyte ratio
have an Effect on Birthweight, Gestational Age and Severity of
Prematurity?
Abstract
ABSTRACT Objective: The aim of this study was to investigate whether the
neutrophil/lymphocyte ratio (NLR) and the platelet/lymphocyte ratio
(PLR) have an effect on birthweight, gestational age and the severity of
prematurity. Design: Retrospective cohort study Setting: Kayseri
Education and Research Hospital Methods: The data of 15000 women who
delivered at the Kayseri Training and Research Hospital between May 2018
and December 2019 were retrospectively scanned. The complete blood count
(CBC) values taken from the patients at least 1 month before the birth
were used in the study. Main Outcome Measures: Primary outcome was to
evaulate the effect of NLR and PLR on prematurity severity, birthweight
and gestational week. Results: A total of 637 patients were included in
the study. The gestational age at birth was determined to be associated
with an increase in maternal Hb value and a decrease in PLR. A decrease
in Hb, PLR, and neutrophil count, and an increase in BMI and NLR were
each determined to be independent factors for birthweight. Conclusion:
This is the first study to have investigated the effect of PLR and NLR
on the severity of prematurity. While no correlation was determined
between the severity of prematurity and NLR, there was seen to be a weak
positive correlation with PLR. Key Words: neutrophil/lymphocyte ratio,
platelet/lymphocyte ratio, prematurity, inflammation, birthweight
Funding: None