Superior vena cava (SVC) isolation improves outcomes in patients with atrial fibrillation (AF). However, right phrenic nerve (PN) injury is a major complication of this procedure. Repeated SVC isolation was performed due to recurrence of SVC-triggered AF. The right atrium (RA)-SVC activation map revealed that the propagation broke through the gap at the PN site from the RA to the SVC. To avoid PN injury, the SVC was isolated by making longitudinal lines on both sides of the PN in a cranial direction. This novel approach of SVC isolation may be an effective therapeutic option to prevent PN injury.