ROLE OF 5-HT1A RECEPTOR FOR HYPOGLYCAEMIC POTENTIAL OF ETHANOLIC EXTRACT
OF CASSIA OCCIDENTALIS LINN. LEAVES IN CHRONIC STRESSED RATS
Background and Purpose Chronic stress affects many physiological
functions in the body leading to number of disorders including diabetes.
Hence present work was designed to study Ethanolic extract of Cassia
occidentalis linn. leaves (ECO) for its hypoglycaemic effect and role of
5-HT1A receptor in chronic stressed rat. Experimental Approach Animals
divided in 5 groups (n=6) and treated with 500 mg/kg p.o. of ECO alone
and in combination with Aripiprazole 2.5mg/kg, i.p. (ECO+ ARI group) and
WAY 100635 (0.3mg/kg, i.p.) (ECO+WAY group) for 28 days to assess its
effect in immobilized stressed rats. Open field and Hole board test were
used for determination of stress in animals followed by blood glucose
level and adrenal gland study. Key Results Animals treated with ECO 500
mg/kg p.o. and ECO+ ARI showed significant (p<0.01) stress
resistant activity as compared to negative control. Whereas ECO+WAY
treated group showed no significant change in stress related behaviour
compared to negative control. Results also demonstrated that there was
significant (p<0.01) decrease in blood glucose level and
weight of adrenal gland in animals treated with ECO and ECO+ ARI.
Whereas, ECO+WAY group showed non-significant change in blood glucose
level and weight of adrenal gland as compared to negative control.
Conclusion and Implications Present study concludes, ECO possess
antistress and hypoglycaemic activity in immobilized stressed rats by
activating 5-HT1A receptor.