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Revisiting Efforts and Advancements in Tracheal Tissue Engineering
  • +3
  • Piyush Agarwal,
  • Pradyumn Agarwal,
  • Ajay Sahi,
  • Neelima Varshney,
  • SURUCHI PODDAR,
  • Sanjeev Kumar Mahto
Piyush Agarwal
Indian Institute of Science
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Pradyumn Agarwal
Indian Institute of Technology Banaras Hindu University
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Ajay Sahi
Indian Institute of Technology Banaras Hindu University
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Neelima Varshney
Indian Institute of Technology Banaras Hindu University
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SURUCHI PODDAR
Indian Institute of Technology Banaras Hindu University
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Sanjeev Kumar Mahto
Indian Institute of Technology Banaras Hindu University
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Abstract

Trachea plays a vital role in the human body for transporting oxygen to the lungs. Tracheal stenosis is one of the destructive conditions that majorly affects the trachea and may lead to the death. Over the several years, research has been directed for the development of biomaterials which can initiate the replacement and regeneration of the trachea and the field is known as tracheal tissue engineering. This review summarizes the efforts in the field of tracheal tissue engineering and its regeneration in terms of the sources of cells, different types of materials used and several types of fabrication techniques such as electrospinning, three-dimensional (3D) bioprinting and decellularisation. We have also discussed possible animal models which could be used for in vivo implantation of the developed substitutes to check its efficacy and biocompatibility. Bioreactors are mandatory equipments for 3D culturing of certain cells inside the developed scaffold and for optimal conditioning of the scaffolds. Therefore, various bioreactor models have also been discussed in detail for scaffold development towards tracheal tissue engineering.