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Three-dimensionally (3D) printing of propolis incorporated sodium alginate scaffolds for wound treatment
  • Muhammet UZUN,
  • Cem ÜSTÜNDAĞ
Muhammet UZUN
Marmara University - Goztepe Campus
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Cem ÜSTÜNDAĞ
Yildiz Technical University
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Abstract

3D printing can be of great use, particularly the production of personal medical products and devices such as scaffolds. In this study, the main aim is to develop propolis (Ps) containing wound dressings by making use of 3D printing technology. Different combinations and structures of propolis (Ps) incorporated sodium alginate (SA) scaffolds are developed. The morphological studies show that the porosity of developed scaffolds was optimized when 20% (v/v) of Ps was added in the solution. The pore sizes decreased by increasing Ps concentration up to a certain level due to its adhesive properties. The mechanical, swelling-degradation (weight loss) behaviors and Ps release kinetics were highlighted for the scaffold stability. The antimicrobial assay was employed to test and screen antimicrobial behaviour of Ps against Escherichia coli and Staphylococcus aureus strains. The results show that the Ps added scaffolds have an excellent antibacterial activity because of Ps’s compounds. The in-vitro cytotoxicity test was also applied on the scaffold by using the extract method on the human dermal fibroblasts (HFFF2) cell line. It is clearly found that the control SA and Ps added SA are non-toxic. The 3D printed SA-Ps scaffolds are very effective structures for wound dressing applications with unique properties.

Peer review status:POSTED

20 Apr 2020Submitted to Biotechnology and Bioengineering
22 Apr 2020Assigned to Editor
22 Apr 2020Submission Checks Completed