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A rationale for targeting the P2X7 receptor in Coronavirus disease 19 (Covid-19)
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  • Francesco Di Virgilio,
  • Yong Tang,
  • Alba Sarti,
  • Marco Rossato
Francesco Di Virgilio
Univ. of Ferrara
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Yong Tang
Chengdu University of Traditional Chinese Medicine
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Alba Sarti
Univ. of Ferrara
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Marco Rossato
University of Padova
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Abstract

Acute respiratory distress syndrome (ARDS) is the main cause of morbidity and mortality in Coronavirus disease 19 (Covid-19) for which as of now there is no effective treatment. ARDS is caused and sustained by an uncontrolled inflammatory activation characterized by a massive release of cytokines (cytokine storm), diffuse lung edema, inflammatory cell infiltraton and disseminated coagulation. Macrophage and T lymphocyte dysfunction plays a central role in this syndrome. In several experimental in vitro and in vivo models, many of these pathophysiological changes are triggered by stimulation of the P2X7 receptor. We hypothesize that this receptor might be an ideal candidate to target in Covid-19-associated ARDS.

Peer review status:ACCEPTED

21 Apr 2020Submitted to British Journal of Pharmacology
22 Apr 2020Submission Checks Completed
22 Apr 2020Assigned to Editor
22 Apr 2020Reviewer(s) Assigned
23 Apr 2020Editorial Decision: Revise Minor
25 Apr 20201st Revision Received
29 Apr 2020Submission Checks Completed
29 Apr 2020Assigned to Editor
30 Apr 2020Reviewer(s) Assigned
03 May 2020Editorial Decision: Accept