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Maternal age as a risk factor in pregnancy and perinatal period: a retrospective cohort study.
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  • Lukasz Pydys,
  • Anna Kajdy,
  • Ewa Dmoch-Gajzlerska,
  • Andrzej Cacko
Lukasz Pydys
Centrum Medyczne Zelazna Sp zoo
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Anna Kajdy
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Ewa Dmoch-Gajzlerska
Medical University of Warsaw
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Andrzej Cacko
Medical University of Warsaw
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Objective The main aim of the study was to assess the influence of maternal age on the incidence of significant pregnancy and childbirth complications in women with low-risk pregnancies. Design A retrospective cohort study. Setting Data collected from hospital delivery admission electronic medical records and discharge summaries of patients hospitalized in St Sophia’s Hospital in 2010-2016. Population or Sample 25063 women with low-risk singleton pregnancies. We excluded all patients with known main comorbidities influencing perinatal outcome. Methods The univariate and multivariate statistical analysis was performed to estimate the impact of age on the primary endpoint. Main Outcome Measures The primary endpoint was defined as a compiled adverse pregnancy outcome, which included several components. Results Maternal age is a significant risk factor for adverse pregnancy outcomes. Each subsequent year of life increases the incidence of pregnancy and childbirth complications (OR 1,014; 95%CI 1,008–1,021). Conclusions Maternal age is an independent risk factor for some of the complications of pregnancy and childbirth. Keywords maternal age, perinatal outcome, advanced maternal age, risk factor