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The role of CD36 in cardiovascular diseases
  • +2
  • shu hong yang,
  • zhou ning,
  • peng yi zhong,
  • hang wei jian,
  • nie jia li
shu hong yang
Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology
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zhou ning
Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology
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peng yi zhong
Wuhan Union Hospital
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hang wei jian
Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology
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nie jia li
Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology
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Abstract

CD36, also known as scavenger receptor B2, is a multifunctional receptor widely expressed in various organs. CD36 plays a crucial role in the uptake of long-chain fatty acids, the main metabolic substrate in myocardial tissue. The maturation and transportation of CD36 was regulated by the post-translational modifications including phosphorylation, ubiquitination, glycosylation, and palmitoylation. CD36 is decreased in pathological cardiac hypertrophy caused by ischemia-reperfusion and pressure overload, while increased in diabetic cardiomyopathy. Deficiency of CD36 alleviate diabetic cardiomyopathy, while overexpression of CD36 eliminates the damage of ischemia-reperfusion, suggesting that CD36 is closely associated with the progression of cardiovascular diseases. and it is expected to be a new therapeutic target. This review summarizes the regulation and post-translational modifications of CD36, and evaluates its role in main cardiovascular diseases and its potential as a therapeutic target.