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Cholesterol and oxysterol sulfates: Physiological roles and analytical challenges
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  • Lorena Diaz Sanchez,
  • Lorenzo Pontini,
  • Maura Marinozzi,
  • Lissette Sanchez-Aranguren,
  • Ana Reis,
  • Irundika Dias
Lorena Diaz Sanchez
Aston University
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Lorenzo Pontini
University of Perugia
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Maura Marinozzi
University of Perugia
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Lissette Sanchez-Aranguren
Aston University
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Ana Reis
University of Porto
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Irundika Dias
Aston University
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Abstract

Cholesterol (Chol) and oxysterol sulfates are important regulators of lipid metabolism, inflammation, cell apoptosis, and cell survival. Among the sulfate-based lipids, cholesterol sulfate (CS) is the most studied lipid both quantitatively and functionally. Despite the importance, very few studies have analysed and linked the actions of oxysterol sulfates to their physiological roles. Over expression of sulfotransferases confirmed the formation of a range of oxysterol sulfates and their antagonistic effects on liver X receptors (LXRs). It is therefore important to understand how further changes to oxysterol/oxysterol sulfate homeostasis can contribute to LXR activity in the physiological milieu. Here, we aim to bring together evidences for novel roles of oxysterol sulfates, the available techniques and the challenges for analysing them. Understanding the oxysterol/oxysterol sulfate levels and their physiological mechanisms could lead to new therapeutic targets for metabolic diseases.

Peer review status:ACCEPTED

22 Apr 2020Submitted to British Journal of Pharmacology
24 Apr 2020Submission Checks Completed
24 Apr 2020Assigned to Editor
29 Apr 2020Reviewer(s) Assigned
02 Jun 2020Editorial Decision: Revise Minor
01 Jul 20201st Revision Received
02 Jul 2020Submission Checks Completed
02 Jul 2020Assigned to Editor
03 Jul 2020Reviewer(s) Assigned
18 Jul 2020Review(s) Completed, Editorial Evaluation Pending
20 Jul 2020Editorial Decision: Accept