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Patient management positive covid: the central role of clinical nutrition and supplementation of essential amino acids during and after hospitalization..
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  • Francesco Ferrara,
  • Giovanni Granata,
  • Chiara Pelliccia,
  • Raffaele La Porta,
  • Antonio Vitiello
Francesco Ferrara
Azienda Unità Sanitaria Locale Umbria 1
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Giovanni Granata
Local Health Authority Salerno
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Chiara Pelliccia
Azienda Unità Sanitaria Locale Umbria 2
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Raffaele La Porta
ASUR Marche
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Antonio Vitiello
Azienda Unità Sanitaria Locale Umbria 1
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Abstract

Background The covid 19 positive patient who is subject to a hyperinflammatory condition associated with lung injury with the development of pneumonia is hospitalized in the intensive care unit. Before resolving and overcoming the “cytokine storm”, with overexpression of pro-inflammatory interleukins (IL-, Il-6), this patient will be intubated for more than 48 hours and therefore needs adequate nutrition. Experimental approach Malnutrition can lead to sarcopenia with a decrease in lean body mass and worsening of the inflammatory state underway. In addition, severe debilitation, if not corrected with adequate nutrition, can greatly lengthen rehabilitation times with prolonged hospitalization, increased costs and reduced turn over already in crisis due to the health emergency caused by coronavirus. Key Results The aim of this study is to focus attention on the nutritional importance that must be provided in case of covid 19 together with pharmacological treatments to lower the number of circulating proinflammatory cytokines. Conclusions Oral, enteral and parenteral nutrition should always be carried out according to the patient’s condition and, in the case of a hyperinflammatory patient, such as the one affected by covid 19, it has been shown that the supplementation of amino acids helps to lower the inflammatory state and promotes normal recovery physiological. Keywords: amino acids, nutrition, covid, glutamine, hyperinflammatory, sarcopenia, cytokine.

Peer review status:POSTED

24 Apr 2020Submitted to British Journal of Pharmacology
27 Apr 2020Assigned to Editor
27 Apr 2020Submission Checks Completed