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LDL receptors, caveolae and cholesterol in endothelial cell dysfunction: oxLDL accomplices or victims?
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  • Francesca Luchetti,
  • Rita Crinelli ,
  • Maria Nasoni ,
  • Serena Benedetti,
  • Francesco Palma,
  • Alessandra Fraternale ,
  • Luigi Iuliano
Francesca Luchetti
University of Urbino Department of Biomolecular Sciences
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Rita Crinelli
University of Urbino Department of Biomolecular Sciences
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Maria Nasoni
University of Urbino Department of Biomolecular Sciences
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Serena Benedetti
University of Urbino Department of Biomolecular Sciences
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Francesco Palma
University of Urbino Department of Biomolecular Sciences
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Alessandra Fraternale
University of Urbino Department of Biomolecular Sciences
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Luigi Iuliano
University of Rome La Sapienza
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Abstract

Oxidized low-density lipoproteins (oxLDL) and oxysterols play a key role in the endothelial dysfunction and atherosclerosis development. Loss of vascular endothelium integrity impacts vasomotion, cell growth, adhesiveness and barrier functions. While for some of these disturbances we can give a reasonable explanation from a mechanistic point of view, for many others the involved molecular players are unknown. Caveolae, specific plasma membrane domains, have recently emerged as targets and mediators of oxLDL-induced endothelial cell dysfunction. The current knowledge on oxLDL/caveolae interplay and the associated signal transduction pathways are here reviewed and discussed in light of the possible cross-talk between transducers (from receptors to membrane cholesterol) and/or effectors. A better understanding of how oxLDL interact with endothelial cells (EC) and, in turn, modulate metabolic/signaling pathways in EC is crucial to define their role in atherogenesis and find new targets of intervention.

Peer review status:ACCEPTED

25 Apr 2020Submitted to British Journal of Pharmacology
27 Apr 2020Submission Checks Completed
27 Apr 2020Assigned to Editor
04 May 2020Reviewer(s) Assigned
25 Jun 2020Review(s) Completed, Editorial Evaluation Pending
29 Jun 2020Editorial Decision: Revise Minor
29 Jul 20201st Revision Received
30 Jul 2020Submission Checks Completed
30 Jul 2020Assigned to Editor
04 Aug 2020Reviewer(s) Assigned
07 Sep 2020Review(s) Completed, Editorial Evaluation Pending
11 Sep 2020Editorial Decision: Accept