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The case for Chronotherapy in COVID-19 induced Acute Respiratory Distress Syndrome (ARDS).
  • +3
  • Faleh Tamimi,
  • Mohammad Abusamak,
  • Bindu Akkanti,
  • Zheng Chen,
  • Seung-Hee Yoo,
  • Harry Karmouty Quintana
Faleh Tamimi
McGill University
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Mohammad Abusamak
McGill University
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Bindu Akkanti
UTHealth
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Zheng Chen
University of Texas Health Science Center at Houston
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Seung-Hee Yoo
University of Texas Health Science Center at Houston
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Harry Karmouty Quintana
UTHealth
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Abstract

COVID-19, the disease resulting from infection by a novel coronavirus: SARS-Cov2 that has rapidly spread since November 2019 leading to a global pandemic. SARS-Cov2 has infected over 2.8 million people and caused over 180,000 deaths worldwide. Although most cases are mild, a subset of patients develop a severe and atypical presentation of Acute Respiratory Distress Syndrome (ARDS) that is characterised by a cytokine release storm (CRS). Paradoxically, treatment with anti-inflammatory agents and immune regulators has been associated with worsening of ARDS. We hypothesize that the intrinsic circadian clock of the lung and the immune system may regulate individual components of CRS and thus chronotherapy may be used to effectively manage ARDS in COVID-19 patients.

Peer review status:ACCEPTED

26 Apr 2020Submitted to British Journal of Pharmacology
28 Apr 2020Submission Checks Completed
28 Apr 2020Assigned to Editor
29 Apr 2020Reviewer(s) Assigned
03 May 2020Editorial Decision: Revise Minor
06 May 20201st Revision Received
08 May 2020Submission Checks Completed
08 May 2020Assigned to Editor
09 May 2020Reviewer(s) Assigned
09 May 2020Editorial Decision: Accept