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Ontogeny of drug metabolism and transport: new data derived by innovative approaches
  • +1
  • Bianca van Groen,
  • Karel Allegaert,
  • Dick Tibboel,
  • Saskia N. de Wildt
Bianca van Groen
Erasmus MC - Sophia Children's Hospital
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Karel Allegaert
KU Leuven
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Dick Tibboel
Erasmus MC - Sophia Children's Hospital
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Saskia N. de Wildt
Radboud Institute of Health Sciences, Radboud University Medical Center
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Abstract

Drug disposition in children is impacted by developmental changes in drug absorption, distribution, metabolism and excretion. This mandates the need for dosing regimens specifically tailored to children. Yet, there are gaps in the knowledge on these developmental changes, for example regarding hepatic and renal drug transport and drug metabolism, putting children at risk for subtherapeutic or toxic drug exposure. Pediatric drug research is faced with ethical and analytical challenges. This review addresses how these knowledge gaps can be filled and challenges can be overcome by using innovative study designs.

Peer review status:ACCEPTED

29 Apr 2020Submitted to British Journal of Clinical Pharmacology
30 Apr 2020Submission Checks Completed
30 Apr 2020Assigned to Editor
04 May 2020Reviewer(s) Assigned
18 May 2020Review(s) Completed, Editorial Evaluation Pending
24 May 2020Editorial Decision: Revise Major
20 Jul 20201st Revision Received
21 Jul 2020Submission Checks Completed
21 Jul 2020Assigned to Editor
21 Jul 2020Review(s) Completed, Editorial Evaluation Pending
29 Jul 2020Editorial Decision: Revise Minor
10 Aug 20202nd Revision Received
11 Aug 2020Submission Checks Completed
11 Aug 2020Assigned to Editor
11 Aug 2020Review(s) Completed, Editorial Evaluation Pending
17 Aug 2020Editorial Decision: Accept