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Off-label drug use in Neonatal Intensive Care Units in China: a descriptive, multicenter study
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  • Meng Lv,
  • Yan Li,
  • Chong Sun,
  • Yuxue Zhou,
  • Shirong Peng,
  • Qingsheng Liu,
  • Li Li,
  • Hongli Chen,
  • Xinsheng Wei,
  • Kaili Li,
  • Zhaohui Li,
  • Wei Hu,
  • Qing Xu
Meng Lv
Children’s Hospital Affiliated to Zhengzhou University
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Yan Li
Children’s Hospital Affiliated to Zhengzhou University
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Chong Sun
Children’s Hospital Affiliated to Zhengzhou University
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Yuxue Zhou
Children’s Hospital Affiliated to Zhengzhou University
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Shirong Peng
Children’s Hospital Affiliated to Zhengzhou University
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Qingsheng Liu
Jiaozuo Maternal and Child Health Care Hospital
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Li Li
Luoyang Maternal and Child Health Care Hospital
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Hongli Chen
Xinxiang Central Hospital
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Xinsheng Wei
Yuzhou City People's Hospital
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Kaili Li
Zhecheng People's Hospital
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Zhaohui Li
Children’s Hospital Affiliated to Zhengzhou University
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Wei Hu
Xinyang Central Hospital
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Qing Xu
Lankao First People's Hospital
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Abstract

Abstract Aim: Off-label drug use in neonates remains a global problem. The retrospective, multicenter study was to study the rates and reasons of off-label drug use among representative NICUs in Henan, China. Methods: Prescriptions were randomized sampled from eight NICUs. Patient characteristics and diseases were collected. Classifications of off-label drug use including age, frequency, dose, indication and route of administration were analyzed. Results: 1770 neonates sampled from eight NICUs were evaluable in the study, with a mean body weight 2.98 kg (SD = 0.80, range 0.78-6.0), 92.03% of whom were exposed to ≥ 1 off-label prescription. 5813 prescriptions with 113 drugs were registered, 84.62% of which were off label. 63.03% of the off-label use was in relation to age. Conclusion: Off-label drug use among neonates remains fairly prevalent in Henan, China. Initiative and effective implementation is urgently required to improve this situation.