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Intranasal Stem Cell Secretome therapy to prevent COVID-19 complications
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  • Avinash Sanap,
  • Ramesh Bhonde,
  • Avinash Kharat,
  • Supriya Kheur
Avinash Sanap
Regenerative Medicine Laboratory, Dr. D. Y. Dental College and Hospital, Pune, India
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Ramesh Bhonde
Dr D Y Patil Vidyapeeth University
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Avinash Kharat
Regenerative Medicine Laboratory, Dr. D. Y. Dental College and Hospital, Pune, India
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Supriya Kheur
Regenerative Medicine Laboratory, Dr. D. Y. Dental College and Hospital, Pune, India
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Abstract

Acute respiratory distress syndrome (ARDS) is the key cause for the morbidity and mortality due to COVID-19 infections. Recent clinical evidences suggest chronic release of pro-inflammatory cytokines as a prominent etiological factor. Adult stem cells are known to secrete potent immunomodulatory and bioactive compounds. We propose a nebulizer assisted treatment of Mesenchymal Stem Cells (MSCs) Secretome as a therapy which will counterbalance the COVID-19 induced cytokine storm as well as promote the regeneration of alveolar tissue attributed to the intrinsic cytokines and growth factor present in the Secretome. Intranasal administration of Secretome will not only protect against the COVID-19 associated complications but also bring down the necessity of the ventilator reducing the burden on health care infrastructure.