Clinical Outcome of Pediatric Ewing Sarcoma and Significance of
Pathological Necrosis after Neoadjuvant Chemotherapy, single
institutional study
Abstract
CLINICAL OUTCOME OF PEDIATRIC EWING SARCOMA AND SIGNIFICANCE OF
PATHOLOGICAL NECROSIS AFTER NEOADHUVANT CHEMOTHERAPY: SINGLE
INSTITUTIONAL STUDY Authors: Sindhu II, Mehreen A, Wali RM, Abubakar M
Affiliation: Shaukat Khanum Memorial Cancer Hospital & Research Center,
Lahore. Pakistan Abstract Purpose: Tumor necrosis and histopathological
changes in Ewing sarcoma following neoadjuvant chemotherapy are
important predictors of disease outcome. The aim of our study is to
determine the clinical outcome and significance of pathological necrosis
after neoadjuvant chemotherapy as it has not been reported in our
country so far. Methods: Data was reviewed after IRB approval from
January 2010 to December 2015 were retrospectively reviewed for patients
with newly diagnosed Ewing sarcoma on histopathology and less than 20
years of age at the time of diagnosis. Results: A Total of 124 patients
were included, in which 89 patients (72%) were non metastatic and 35
patients were metastatic (28%). Histopathology report after doing
surgery showed Little or no (Grade 1 ) necrosis seen in 14 patients
(11%) and 50-90% (Grade II) necrosis seen in 9 patients (7%), 90-99%
(Grade III) necrosis seen in 8 patients (5.5%), and 100% (Grade IV)
necrosis in 14 patients (11%). EFS of grade 4 necrosis was 93%,
grade-3 71%, grade- 2 22% and grade-1 35%. OS of grade 4 necrosis was
93%, grade -3 75%, grade-2 25 % and grade-1 50%. EFS of Ewing
sarcoma patients were 38% and OS was 38%. Conclusion: Tumor necrosis
and histopathological changes after surgery has great impact on survival
outcome in Ewing Sarcoma.