loading page

Effect of exogenous insulin on platelet reactivity in patients with acute ischemic vascular events
  • +2
  • Qi Ma,
  • xiaodan Wen,
  • Qian Wang,
  • Yunlian Xue,
  • Li'an Huang
Qi Ma
Guangdong Geriatrics Institute
Author Profile
xiaodan Wen
Guangdong Geriatrics Institute
Author Profile
Qian Wang
Guangdong Geriatrics Institute
Author Profile
Yunlian Xue
Guangdong Provincial People's Hospital
Author Profile
Li'an Huang
Jinan University First Affiliated Hospital
Author Profile

Abstract

Objective: Recent studies have shown that insulin therapy increased the risk of major cardiovascular adverse events, and the changes of platelet reactivity may be responsible for the clinical outcomes. We attempted to explore the effect of exogenous insulin on platelet function in patients with type 2 diabetes mellitus who were suffering from acute vascular events. Methods: We collected data of 540 diabetes patients with acute ischemic vascular events from the hospital information system. Their platelet reactivity has been reported by the maximum amplitude of adenosine diphosphate-induced platelet-fibrin clots (MAADP) of thromboelastography. The effect of antidiabetic drugs on platelet reactivity was analyzed retrospectively. Stratified regression analysis was carried out to gradually adjust for the demographic data, genetic factors, lifestyle, biochemical indicators, antiplatelet regimen, etc. Results: Univariate linear regression analysis showed that sex, age, body mass index, smoking, low-density lipoprotein, platelet count, CYP2C19*2, antiplatelet regimens, and insulin were related to MAADP. After multiple factors were adjusted, the effect of insulin therapy (95% CI: 0.022-0.664; p =0.036) on MAADP was always statistically significant. Conclusions: Exogenous insulin effects significantly on the level of MAADP in diabetic patients with acute ischemic vascular events, which may be not conducive to antiplatelet therapy.

Peer review status:UNDER REVIEW

25 May 2020Submitted to International Journal of Clinical Practice
26 May 2020Assigned to Editor
26 May 2020Submission Checks Completed
01 Jun 2020Reviewer(s) Assigned