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Early risk factors for re-detectable positive in the recovered COVID-19 children
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  • Denggao Peng,
  • Jing Zhang,
  • Yiling Ji,
  • Dongming Pan
Denggao Peng
The Third People's Hospital of Shenzhen
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Jing Zhang
The Third People's Hospital of Shenzhen
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Yiling Ji
The Third People's Hospital of Shenzhen
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Dongming Pan
The Third People's Hospital of Shenzhen
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Abstract

Background and Objective: Compared with adult patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), children have a higher proportion of re-detectable positive (RP) in the recovery period.The underlying risk factors remain unknown.We aimed to identify the early risk factors for RP, and to provide a basis for early clinical prediction and risk stratification. Methods: A retrospective analysis was performed on all pediatric cases diagnosed with coronavirus disease 2019 (COVID-19). Results: 14 of 38 (36.8%) pediatric patients were RP.Children have a significantly higher percentage of RP (OR[95%CI] 4.84[2.21-10.59];P=.000).Compared with control group (n=24),RP group (n=14) had more family cluster infections (1.59[1.1-2.3];P=.030),while age ([7.2±4.8] vs [7.6±5.1]),and percentage of male gender (35.7% vs 45.8%), fever (21.4% vs 45.8%),respiratory or digestive symptoms (71.4% vs 50%), asymptom (28.6% vs 33.3%), computed tomography positive findings (85.7% vs 83.3%) and co-infection (7.1% vs 8.3%) were statistically nonsignificant.The laboratory data of RP group had a relatively higher white blood cell count (WBC) (7.5[5.1-9.8] vs 4.8[4.4-7.5];P=.009) and longer plasma prothrombin time (PT) ([12.6±0.7] vs [12.1±0.5];P=.023),while neutrophil percentage and count, lymphocyte percentage and count, hemoglobin, platelets,erythrocyte sedimentation rate,high sensitivity C-reactive protein, interleukin 6,procalcitonin, activated partial thromboplastin time ([37.5±4.6] vs [34.2±5.1]; P=.057),fibrinogen,antithrombin III and D-dimer showed no statistical difference. Conclusions:Family cluster infection,higher WBC and longer PT are the main risk factors for RP in the recovered COVID-19 children.Early activation of coagulation and WBC may be involved in SARS-CoV-2 clearance.

Peer review status:UNDER REVIEW

25 May 2020Submitted to Pediatric Pulmonology
26 May 2020Submission Checks Completed
26 May 2020Assigned to Editor
27 May 2020Reviewer(s) Assigned
24 Jun 2020Review(s) Completed, Editorial Evaluation Pending
27 Jun 2020Editorial Decision: Revise Major
29 Jul 20201st Revision Received
29 Jul 2020Assigned to Editor
29 Jul 2020Submission Checks Completed
29 Jul 2020Reviewer(s) Assigned
20 Aug 2020Review(s) Completed, Editorial Evaluation Pending
21 Aug 2020Editorial Decision: Revise Minor
01 Sep 20202nd Revision Received
02 Sep 2020Submission Checks Completed
02 Sep 2020Assigned to Editor
02 Sep 2020Reviewer(s) Assigned
13 Sep 2020Review(s) Completed, Editorial Evaluation Pending
16 Sep 20203rd Revision Received
17 Sep 2020Submission Checks Completed
17 Sep 2020Assigned to Editor
17 Sep 2020Reviewer(s) Assigned