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Homemade valved holding chambers for children with airway hyperresponsiveness
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  • Kesanee Chaicoming,
  • Aroonwan Preutthipan,
  • Anusorn Adelekkittikun,
  • Malinee Nugboon
Kesanee Chaicoming
Mahidol University Faculty of Medicine Ramathibodi Hospital
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Aroonwan Preutthipan
Mahidol University Faculty of Medicine Ramathibodi Hospital
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Anusorn Adelekkittikun
Mahidol University Faculty of Medicine Ramathibodi Hospital
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Malinee Nugboon
Mahidol University Faculty of Medicine Ramathibodi Hospital
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Abstract

Background: During COVID-19 pandemic, a metered-dose inhaler (MDI) with a valved holding chamber (VHC) is a preferred route of bronchodilator delivery. We have developed a new homemade VHC, made of a paper coffee cup and a drinking water bottle. This study was conducted to compare the bronchodilator response in children with airway hyperresponsiveness after the use of our homemade VHC and that of a standard commercial one. Methods: In a randomized, two-period, two-sequence crossover design, we recruited 20 children, aged 6-15 years, who had greater than 12% increase in FEV1 after inhaled salbutamol. They were randomized into Group A and B. Group A used our VHC on the first day and Aerochamber® on the second day. Group B used the same VHCs but in alternate sequence. Spirometries were performed before and after 400 microgram of salbutamol MDI was administered via those VHCs. Results: Baseline demographic data and spirometric values did not have statistically significant differences between group A and B and between the first and second day (P > 0.05). After giving salbutamol MDI, both VHCs produced significant increases in FVC, FEV1 and FEF25-75% (P < 0.005). The improvement in FEV1 did not significantly differ between our homemade VHC and Aerochamber® (P > 0.05). Conclusion: Our homemade VHC is effective for an MDI bronchodilator delivery. Since it is very cheap and easy to make, it may be used as a disposable device to minimize airborne transmission especially when commercial VHC are not available.

Peer review status:ACCEPTED

23 May 2020Submitted to Pediatric Pulmonology
26 May 2020Submission Checks Completed
26 May 2020Assigned to Editor
30 May 2020Reviewer(s) Assigned
15 Jun 2020Review(s) Completed, Editorial Evaluation Pending
15 Jun 2020Editorial Decision: Revise Major
24 Sep 20201st Revision Received
25 Sep 2020Submission Checks Completed
25 Sep 2020Assigned to Editor
25 Sep 2020Reviewer(s) Assigned
25 Sep 2020Review(s) Completed, Editorial Evaluation Pending
25 Sep 2020Editorial Decision: Revise Minor
10 Oct 20202nd Revision Received
12 Oct 2020Submission Checks Completed
12 Oct 2020Assigned to Editor
13 Oct 2020Review(s) Completed, Editorial Evaluation Pending
14 Oct 2020Editorial Decision: Accept