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Hydrogel-based 3D bioprinting: for bone and cartilage tissue engineering
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  • Parinaz Abdollahian,
  • Miguel de la Guardia,
  • Fatemeh Oroojalian,
  • Ahad Mokhtarzadeh
Parinaz Abdollahian
Tabriz University of Medical Sciences
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Miguel de la Guardia
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Fatemeh Oroojalian
North Khorasan University of Medical Sciences
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Ahad Mokhtarzadeh
Tabriz University of Medical Sciences
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Abstract

As a milestone in soft and hard tissue engineering, a precise control over the micropatterns of scaffolds have lightened new opportunities for the recapitulation of native body organs through 3D bioprinting approaches. Well-printable bioinks are pre-requisites for the bioprinting of tissues/organs where hydrogels play a critical role. Despite the outstanding developments in 3D engineered microstructures, current printer devices, suffer from the risk of exposing loaded living agents to mechanical (nozzle-based) and thermal (nozzle-free) stresses. Thus, tuning the rheological, physical, and mechanical properties of hydrogels are promising solutions to address these issues. The relationship between the mechanical characteristics of hydrogels and their printability is important to control printing quality and fidelity. Recent developments in defining this relationship have highlighted the decisive role of main additive manufacturing strategies. These strategies are applied to enhance the printing quality of scaffolds and determine the nurture of cellular morphology. In this regard, it is beneficial to use external and internal stabilization, photo curable biopolymers, and cooling substrates containing the printed scaffolds. The objective of this study was to review cutting-edge developments in hydrogel-type bioinks and discuss the optimum simulation of the zonal stratification in osteochondral and cartilage units.

Peer review status:Published

30 May 2020Submitted to Biotechnology Journal
01 Jun 2020Submission Checks Completed
01 Jun 2020Assigned to Editor
01 Jun 2020Reviewer(s) Assigned
23 Jun 2020Editorial Decision: Revise Major
07 Jul 20201st Revision Received
08 Jul 2020Submission Checks Completed
08 Jul 2020Assigned to Editor
08 Jul 2020Reviewer(s) Assigned
13 Jul 2020Editorial Decision: Revise Major
22 Jul 20202nd Revision Received
27 Jul 2020Submission Checks Completed
27 Jul 2020Assigned to Editor
27 Jul 2020Reviewer(s) Assigned
30 Jul 2020Editorial Decision: Accept
31 Aug 2020Published in Biotechnology Journal on pages 2000095. 10.1002/biot.202000095