Abstract
Liquid-liquid phase separation (LLPS) of biomolecules has been
investigated intensively in recent years, which underlies the formation
of membrane-less organelles (MLOs) or biomolecular condensates. It
contributes to the regulation of various physiological process and
related disease development. Rapidly increasing number of studies have
recently focused on the biological functions, driving and regulating
mechanisms of LLPS in cell. Based on the mounting data generated in the
investigations, six databases (LLPSDB, PhaSePro, PhaSepDB, DrLLPS,
RNAgranuleDB, HUMAN CELL MAP) have been developed, designed directly
based on LLPS studies or the components identification of MLOs. These
resources are invaluable for deeper understanding of cellular function
of biomolecular phase separation, as well as development of phase
separating protein prediction and design. In this review, we summarize
the data contents, annotations and organization for each of these
databases, highlight their unique features, overlaps and fundamental
differences, and further discuss their suitable applications.