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Pancreas tissue concentration and pharmacokinetics analysis of vancomycin for severe acute pancreatitis: a case report
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  • Chuhui Wang,
  • Xiao-Xiao LI,
  • Chao Li,
  • Na He,
  • Qing-gang Ge,
  • Suo-Di Zhai
Chuhui Wang
Peking University Third Hospital
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Xiao-Xiao LI
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Chao Li
Peking University Third Hospital
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Na He
Peking University Third Hospital
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Qing-gang Ge
Peking University Third Hospital
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Suo-Di Zhai
Peking University Third Hospital
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Abstract

Antibiotic concentration in pancreas tissue is very important for the treatment of severe acute pancreatitis (SAP) with infection. We report a case of a 44-year-old female with SAP on treatment of vancomycin. The time courses of vancomycin concentration in serum and pancreas tissue of the patient was described. This case demonstrated that it took about 30 minutes for vancomycin to get through from serum to pancreas tissue and about 76% of vancomycin could move into pancreas tissue for SAP patients.