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Echocardiographic reference ranges for normal cardiac Doppler data in healthy Turkish population : ECHO-DOP-TR Trial
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  • Özgen Şafak,
  • Mustafa Gürsoy,
  • Sadik Emren,
  • Emre Demir,
  • Tarik Yildirim,
  • Onur Argan,
  • Ersin Simsek,
  • Fatih Aytemiz,
  • Emre Özdemir,
  • Nermin Bayar,
  • Zehra Erkal,
  • Oguzhan Celik,
  • Onur Akhan,
  • Cevdet Dönmez,
  • Tugba Kemaloglu Oz,
  • Serdar Akyel,
  • Oktay Ergene,
  • Mehmet Ozkan
Özgen Şafak
Balikesir University Faculty of Medicine
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Mustafa Gürsoy
Izmir Katip Celebi University Faculty of Medicine
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Sadik Emren
Izmir Katip Celebi University Faculty of Medicine
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Emre Demir
Ege University Faculty of Medicine
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Tarik Yildirim
Balikesir University Faculty of Medicine
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Onur Argan
Balikesir University Faculty of Medicine
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Ersin Simsek
Balıkesir State Hospital
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Fatih Aytemiz
Manisa State Hospital
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Emre Özdemir
Izmir Katip Celebi University Faculty of Medicine
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Nermin Bayar
Antalya Education and Research Hospital
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Zehra Erkal
Antalya Training and Research Hospital
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Oguzhan Celik
Hitit University Faculty of Medicine
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Onur Akhan
Bilecik State Hospital
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Cevdet Dönmez
Dr Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital
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Tugba Kemaloglu Oz
Liv Hospital
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Serdar Akyel
Kastamonu University Faculty of Medicine
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Oktay Ergene
Dokuz Eylül University
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Mehmet Ozkan
Kosuyolu Kartal Heart Education and Research Hospital
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Abstract

Aim Doppler echocardiography has become the standard imaging modality for diastolic function and provide pathophysiological insight into systolic and diastolic heart failure. In this study we aimed to obtain normal echocardiographic Doppler parameters of healthy Turkish population. Methods Among 31 collaborating institutions from all regions of Turkey, 1154 healthy volunteers were enrolled in this study. Predefined protocols were used for all participants during echocardiographic examination and The American Society of Echocardiography and European Association of Cardiovascular Imaging recommendations were used for echocardiographic Doppler measurements. Results A total of 967 healthy participants were enrolled in this study after applying exclusion criteria. Echocardiographic examination was obtained from all subjects following predefined protocols. Mitral E wave velocity and E/A ratio were higher in females and decreased progressively in advancing ages. E wave deceleration time and A wave velocity were increased with aging. Assessment of tissue Doppler velocities showed that left ventricular lateral e’, septal e’ and septal s’ were higher in younger subjects and in females. E/e’ ratio was increased progressively with advancing decades. Right ventricular e’and s’ were decreased but a’ was increased with increasing age. Septal e’ lower than 8 cm/s was 1.9% in the fifth decade and 13.7% in ages older than 50-years. The E/e’ ratio greater than 15 (and also 13) was not found. Conclusion This study, for the first time, provides echocardiographic reference ranges for normal cardiac Doppler data in healthy Turkish population which will be useful in routine clinical practice as well as in future clinical trials.

Peer review status:ACCEPTED

30 May 2020Submitted to Echocardiography
01 Jun 2020Submission Checks Completed
01 Jun 2020Assigned to Editor
01 Jun 2020Reviewer(s) Assigned
24 Jul 2020Review(s) Completed, Editorial Evaluation Pending
24 Jul 2020Editorial Decision: Revise Minor
28 Jul 20201st Revision Received
29 Jul 2020Submission Checks Completed
29 Jul 2020Assigned to Editor
29 Jul 2020Review(s) Completed, Editorial Evaluation Pending
29 Jul 2020Editorial Decision: Accept