Acute Myeloid Leukemia with Monosomy 7 in Sickle Cell Disease Post T
Cell Replete Haploidentical Hematopoietic Stem Cell Transplant: Brief
Hematopoietic Stem Cell Transplant (HSCT) is increasingly being used as
a curative treatment for various malignant and non-malignant conditions.
Second malignancies are known long term complication post HSCT. Myeloid
malignancies rarely occur post allogenic HSCT. To the best of our
knowledge there are no reported case of myeloid malignancy occurring in
sickle cell disease (SCD) patient post haploidentical HSCT. We report 2
patients with SCD, who developed Acute Myeloid Leukemia (AML) with
monosomy 7 post HSCT. Long-term follow-up is needed post allogenic HSCT
even if done for benign conditions like SCD with no prior chemotherapy
or malignancy history.