loading page

LUNG ULTRASOUND SCORE AND DIURETICS IN PRETERM INFANTS BORN BEFORE 32 WEEKS
  • +3
  • Almudena Alonso-Ojembarrena,
  • Alfonso María Lechuga Sancho,
  • Patricia Morales-Arandojo,
  • Silvia Acuñas-Soto,
  • Rosa López-de-Francisco,
  • Simon Lubian-Lopez
Almudena Alonso-Ojembarrena
Hospital Universitario Puerta del Mar
Author Profile
Alfonso María Lechuga Sancho
Hospital Universitario Puerta del Mar
Author Profile
Patricia Morales-Arandojo
Hospital Universitario Puerta del Mar
Author Profile
Silvia Acuñas-Soto
Hospital Universitario Puerta del Mar
Author Profile
Rosa López-de-Francisco
Hospital Universitario Puerta del Mar
Author Profile
Simon Lubian-Lopez
Hospital Universitario Puerta del Mar
Author Profile

Abstract

OBJECTIVE To describe if weekly determined lung ultrasound (LU) scores in preterm infants born before 32 weeks (PTB32W) change with diuretic therapy. DESIGN This is a secondary analysis of a prospective study about weekly performed LU in PTB32W: we included infants who received diuretics, and compared LU scores according to their evolution on respiratory support (RS) before and after diuretics. RESULTS We included 17 PTB32W. Both groups were similar in terms of median gestational age: 26 weeks (interquartile rank (IQR) 25-28) in the responders group, and 27 weeks (IQR 25-29) in the other; but different in median number of days on invasive mechanical ventilation: 27 (IQR 11-43) vs. 76 (IQR 35-117) in the non-responders group, p=0.03; and number of infants with moderate-severe bronchopulmonary dysplasia: 2 (25%) vs. 8 (89%), p=0.005. The responders group showed lower LU scores at one week after diuretics: median LU score 3 (IQR 0-10) vs. 12 (IQR 12-12) in the non-responders group, p=0.04; and after three weeks of treatment: median value 6 (IQR 3-6) in the responders group vs. 12 (10-15) in the non-responders group, p=0.01. The decrease in RS was achieved since the beginning of diuretics: 4 out of 8 (50%) were extubated in the responders group, and 8 out of 9 (11%) in the non-responders group, p=0.048. CONCLUSIONS There is a group of PTB32W whose LU score improves after diuretics. This change appears later than that observed in the RS.

Peer review status:ACCEPTED

01 Jun 2020Submitted to Pediatric Pulmonology
02 Jun 2020Submission Checks Completed
02 Jun 2020Assigned to Editor
03 Jun 2020Reviewer(s) Assigned
15 Jun 2020Review(s) Completed, Editorial Evaluation Pending
04 Jul 2020Editorial Decision: Revise Major
02 Sep 20201st Revision Received
03 Sep 2020Submission Checks Completed
03 Sep 2020Assigned to Editor
03 Sep 2020Reviewer(s) Assigned
16 Sep 2020Review(s) Completed, Editorial Evaluation Pending
23 Sep 2020Editorial Decision: Accept