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Pseudomonas aeruginosa among Cystic Fibrosis patients: epidemiology, risk factors and infection control
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  • Aysegul Karahasan,
  • Gamze Alci,
  • Can Akin,
  • Ayca Cakan,
  • Eren Sarioglu,
  • Batuhan Basci,
  • Yasemin Gokdemir,
  • Ela Eralp,
  • Bulent Karadag
Aysegul Karahasan
Marmara University Training and Research Hospital
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Gamze Alci
Marmara University Training and Research Hospital
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Can Akin
Marmara University School of Medicine
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Ayca Cakan
Marmara University School of Medicine
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Eren Sarioglu
Marmara University School of Medicine
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Batuhan Basci
Marmara University School of Medicine
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Yasemin Gokdemir
Marmara University Training and Research Hospital
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Ela Eralp
Marmara University Training and Research Hospital
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Bulent Karadag
Marmara University Faculty of Medicine
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Abstract

Introduction and Objective: Microbiological surveillance guides the antibiotic therapy that plays an important role in maintaining the cystic fibrosis (CF) patients in stable clinical condition. Materials and Method: Respiratory samples (495 sputum, 711 deep pharyngeal swab) from 253 CF patients aged 0-43 were cultivated in conventional media and cumulative antibiogram was determined. A 24 questioned survey was applied to 119 patients for a 3 months period to measure demographic variabilities and knowledge about infection control. Results: The most common pathogen was Pseudomonas aeruginosa (45.7%), followed by Staphylococcus aureus (36%). P. aeruginosa was isolated from 60% of sputum samples and 28.5% of deep pharyngeal swab samples. High rate of resistance was detected to ceftazidime, amikacin and ciprofloxacin that are often preferred in treatment. Low monthly income, more than 9 visits to CF clinic in the last year, hospitalisation in the last year, spending more than 3 hours in CF clinic were significantly associated with P. aeruginosa colonisation. Health care providers was the main source of information (62.2% ).Vast majority of the patients (88.2%) knew that pathogens can be transmitted between the patients and infections could be reduced by using a mask, handwashing and by cleaning nebulizers as declared by 87.4% of participants clean the nebulizer after every usage and 93.3% of them dry it properly. Conclusion: Prevention of infections in CF patients is possible only if patients and their families are alert and have sufficient information about infection control that will provide great improvements in the prognosis. Key Words: P. aeruginosa, Cystic Fibrosis, Antibiotic Resistance, Infection control

Peer review status:UNDER REVIEW

03 Jun 2020Submitted to Pediatric Pulmonology
04 Jun 2020Assigned to Editor
04 Jun 2020Submission Checks Completed
06 Jun 2020Reviewer(s) Assigned
19 Jul 2020Review(s) Completed, Editorial Evaluation Pending