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Phylogenetic analysis of first Bangladeshi SARS-CoV-2 strain isolated in Bangladesh understanding the possible origin and novel mutations
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  • Otun Saha,
  • Md Miraj Kobad Chowdhury,
  • Md. Shahadat Hossain,
  • Afroza Sultana,
  • Md. Mizanur Rahaman
Otun Saha
Dhaka University
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Md Miraj Kobad Chowdhury
Dhaka University
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Md. Shahadat Hossain
Noakhali Science and Technology University
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Afroza Sultana
Noakhali Science and Technology University
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Md. Mizanur Rahaman
Dhaka University, University of Dhaka
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Abstract

Severe acute respiratory syndrome virus 2 (SARS-CoV-2), the causative agent of the ongoing pandemic of COVID-19 has already marched across 210 countries globally. This novel coronavirus is highly infectious and left us with no available cure and only with containment option. To understand the molecular epidemiology and vaccine design, genetic sequences from different regions are published and analyzed. Here, the first published whole genome sequence of Bangladesh was compared with Asian countries as well as representative strains from across the globe. Phylogenetic analysis of the first Bangladeshi genome, that was published on May 12, 2020 revealed at least 9 Single nucleotide polymorphisms from the Wuhan, China strains and 2 of these mutations are novel compared to the strains analyzed. Among the novel mutations nucleotide 1163 mutation is very novel when compared with all the genomes deposited at Global Initiative on Sharing Avian Influenza Data (GISAID). However, the other mutation at nucleotide 17019, mutation NSP13 E261D is occurred second time after a strain from Austrian patient showed the similar mutation. Structure and screening results of both novel mutation were discussed in detail. Further analysis of these identified novel mutations will boost the understanding of the behavior of SARS-CoV-2 in this region and vaccination and drug development programs would be beneficial.