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Salvage chemotherapy after failure of targeted therapy in a child with BRAF V600E low grade glioma
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  • Musthafa Raswoli,
  • Liana Nobre,
  • Cynthia Hawkins,
  • Ute Bartels,
  • Uri Tabori,
  • Eric Bouffet
Musthafa Raswoli
Hospital for Sick Children

Corresponding Author:[email protected]

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Liana Nobre
Hospital for Sick Children
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Cynthia Hawkins
The Hospital for Sick Children
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Ute Bartels
The Hospital for Sick Children
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Uri Tabori
The Hospital for Sick Children , toronto
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Eric Bouffet
Hospital for Sick Children
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Abstract

Targeted therapies are increasingly used in the management of pediatric low grade glioma. How-ever for patients who show resistance to these treatments, limited options are available. We pre-sent the case of a patient with BRAFV600 mutated low grade glioma who showed progression on a combination of trametinib and dabrafenib. Discontinuation of treatment was associated with a life-threatening deterioration and reintroduction of targeted therapy had no effect. The patient eventually showed a dramatic response to TPCV (thiguanine, procarbazine, CCNU and vincris-tine) , which suggests a role of chemotherapy in these situations.
18 Jul 2020Published in Pediatric Blood & Cancer. 10.1002/pbc.28561