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Isolated Optic Nerve Leukemic Relapse Diagnosed via Fine Needle Aspiration Biopsy and Transconjunctival Biopsy
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  • Kerri McInnis-Smith,
  • Lisa Mansueto,
  • Kristian Schafernak,
  • Jeffrey Jacobsen,
  • Michael Henry,
  • Aparna Ramasubramanian
Kerri McInnis-Smith
Mayo Clinic Arizona
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Lisa Mansueto
Ophthalmic Surgeons & Physicians
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Kristian Schafernak
Phoenix Children's Hospital
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Jeffrey Jacobsen
Phoenix Children's Hospital
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Michael Henry
Phoenix Children's Hospital
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Aparna Ramasubramanian
Phoenix Children's Hospital
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Abstract

Pre-B cell acute lymphoblastic leukemia (ALL) is a hematologic malignancy that arises from overproduction of immature lymphoid cells. ALL has a propensity for recurring in the bone marrow and/or extramedullary sites following complete remission. We present the case of a young male with a history of pre-B cell ALL who presented with leukemic recurrence isolated to the optic nerve. Transvitreal fine needle aspiration biopsy followed by transconjunctival optic nerve biopsy confirmed the diagnosis of ALL relapse and should be considered helpful diagnostic tools in the setting of suspected optic nerve malignancy with otherwise negative workup.