Correlation Among Different Stages of Physiological Cycles and Sudden
Sensorineural Hearing Loss in Female
Abstract: Objectives: Sudden deafness, also known as sudden
sensorineural hearing loss (SSNHL), has numbers hypotheses about its
etiology. One of them believes that changes in sex hormone levels may
increase the risk of thrombosis and block the cochlear microcirculation,
leading to the occurrence of SSNHL. Design: Women in different periods
of physiological cycles, the levels of sex hormones in their body will
change significantly, which had correlated to SSNHL. Participants: This
study collected 435 female subjects who were admitted to the
otolaryngology clinic of our hospital from July 2017 to November 2019.
Setting: The participants were grouped by the menstrual cycle. Main
outcome measures: The pure tone audiometry test results of the subjects
were recorded and the differences among the groups were be analyzed.
Results: 1. There was a significant difference in the average hearing
threshold of subjects in different periods (F(3, 774)=8.773,
P<0.001), and the average hearing threshold in follicular
period (35.44 dBHL) was significantly lower than that in menstrual
period (51.09 dBHL, P<0.001), luteal period (42.69 dBHL,
P=0.036) and menopause (47.39 dBHL, P<0.001); 2. There was a
correlation between the subjects at different periods and the severity
of SSNHL (2 = 38.587, P <0.001), and the SSNHL severity was
the slightest in the follicular period according to the mean rank value.
3. The analysis of SSNHL typing of subjects at different periods were
variously (2 = 38.568, P < 0.001). Conclusions: The results
of this study can explain the effect of sex hormone on SSNHL to a
certain extent, and we will further explore the relationship between sex
hormone levels and SSNHL, in order to provide more support for the
diagnosis and treatment of SSNHL.