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COVID-19 severity declines over time
  • +2
  • Christian Gortazar,
  • Francisco Rodríguez del Río,
  • Dolores Hervás,
  • Lucas Dominguez,
  • Jose de la Fuente
Christian Gortazar
IREC
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Francisco Rodríguez del Río
Servicio de Salud, Horcajo de Los Montes, Ciudad Real
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Dolores Hervás
Servicio de Salud, Horcajo de Los Montes
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Lucas Dominguez
Universidad Complutense de Madrid
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Jose de la Fuente
IREC
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Abstract

The first SARS-CoV-2 pandemic has affected most countries causing hundreds of thousands of deaths. Evolution of the pandemic may involve endemicity with or without significant secondary waves. We observed that disease severity (p=0.006) and duration of symptoms (p<0.001) declined over time in an isolated rural community. This decline was not driven by changes in patient age structure nor by changes in temperature or precipitations. The underlying mechanism may be relevant for COVID-19 management.