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Spotlight on microRNAs in allergy and asthma
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  • Julie Weidner,
  • Sabine Bartel,
  • Ayse Kilic,
  • Ulrich Zissler,
  • Harald Renz,
  • Jürgen Schwarze,
  • Carsten Schmidt-Weber,
  • Tania Maes,
  • Ana Rebane,
  • Susanne Krauss-Etschmann,
  • Madeleine Rådinger
Julie Weidner
University of Gothenburg, Institute of Medicine
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Sabine Bartel
Universitair Medisch Centrum Groningen
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Ayse Kilic
Brigham and Women’s Hospital
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Ulrich Zissler
ZAUM – Center for Allergy and Environment
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Harald Renz
Philipps University
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Jürgen Schwarze
University of Edinburgh, Edinburgh
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Carsten Schmidt-Weber
ZAUM – Center for Allergy and Environment
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Tania Maes
Ghent University
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Ana Rebane
University of Tartu
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Susanne Krauss-Etschmann
Forschungszentrum Borstel Leibniz-Zentrum fur Medizin und Biowissenschaften
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Madeleine Rådinger
University of Gothenburg
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Abstract

In past ten years, microRNAs (miRNAs) have gained scientific attention due to their importance in the pathophysiology of allergic diseases and their potential as biomarkers in liquid biopsies. They act as master post-transcriptional regulators that control most cellular processes. As one miRNA can target several mRNAs, often within the same pathway, dysregulated expression of miRNAs may alter particular cellular responses and contribute or lead to the development of various diseases. In this review, we give an overview of the current research on miRNAs in allergic diseases, including atopic dermatitis, allergic rhinitis and asthma. Specifically, we discuss how individual miRNAs function in the regulation of immune responses in epithelial cells and specialized immune cells in response to different environmental factors and respiratory viruses. In addition, we review insights obtained from experiments with murine models of allergic airway and skin inflammation and offer an overview of studies focusing on miRNA discovery using profiling techniques and bioinformatic modelling of the network effect of multiple miRNAs. In conclusion, we highlight the importance of research into miRNA function in allergy and asthma to improve our knowledge of the molecular mechanisms involved in the pathogenesis of this heterogeneous group of diseases.

Peer review status:IN REVISION

12 Jun 2020Submitted to Allergy
12 Jun 2020Assigned to Editor
12 Jun 2020Submission Checks Completed
15 Jun 2020Reviewer(s) Assigned
26 Jun 2020Review(s) Completed, Editorial Evaluation Pending
03 Jul 2020Editorial Decision: Revise Minor