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The potential threat of multisystem inflammatory syndrome in children during the COVID-19 pandemic
  • Hussin Rothan,
  • Siddappa Byrareddy
Hussin Rothan
Georgia State University
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Siddappa Byrareddy
University of Nebraska Medical Center
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Abstract

Multisystem inflammatory syndrome in children (MIS-C) during the COVID-19 pandemic raised a global alert from the Centers for Disease Control and Prevention’s Health Alert Network. The main manifestations of MIS-C in the setting of a severe inflammatory state include fever, diarrhea, shock, and variable presence of rash, conjunctivitis, extremity edema, and mucous membrane changes, and in some cases it progressed to multi-organ failure. The low percentage of children with asymptomatic cases compared with mild illness and moderate illness could be correlated with the rare cases of MIS-C. One potential explanation for the progression to severe MIS-C disease despite the presence of readily detectable anti-SARS-CoV-2 antibodies could be due to potential role of antibody-dependent enhancement (ADE). We reason that the incidence of the ADE phenomenon whereby the pathogen-specific antibodies can promote pathology should be considered in vaccine development against SARS-COV-2.

Peer review status:ACCEPTED

14 Jun 2020Submitted to Pediatric Allergy and Immunology
17 Jun 2020Reviewer(s) Assigned
18 Jun 2020Review(s) Completed, Editorial Evaluation Pending
24 Jun 2020Editorial Decision: Revise Major
04 Jul 20201st Revision Received
05 Jul 2020Review(s) Completed, Editorial Evaluation Pending
06 Jul 2020Reviewer(s) Assigned
29 Jul 2020Editorial Decision: Revise Major
15 Aug 20202nd Revision Received
18 Aug 2020Review(s) Completed, Editorial Evaluation Pending
18 Aug 2020Reviewer(s) Assigned
26 Aug 2020Editorial Decision: Accept