Study on the differential proteins in plasma of the BPD sensitive to
dexamethasone therapy
Abstract
Abstract Objective To find some plasma differential proteins in
Bronchopulmonary dysplasia(BPD) sensitive to dexamethasone
therapy.Methods 30 cases of BPD from NICU of the affiliated Huaian first
people’s hospital of Nanjing Medical University were selected,the plasma
samples were collected before a 10-day course dexamethasone therapy for
all objects,and the therapeutic effect was judged sooner after the
therapy finished.The infants who showed significant therapeutic effect
were collected the plasma samples again.Then,3 infants were
picked at random from the dexamethasone sensitive infants ,whose plasma
samples before and after dexamethasone therapy were analyzed by DIA,and
the differential proteins were found and analyzed by
bioinformatics.Results 10 of 30 cases were sensitive to
dexamethasone.There are 23 differential proteins between two
groups(before and after dexamethasone administration) in total, from
which, 27 proteins are downregulated,while 6 upregulated. Bioinformatics
analysis showed that differential proteins may involve multiple genes
and signal pathways..When combined with literature retrieval,both
low-density lipoprotein receptor-related protein 1(LRP1) and S100A8
might be consindered as potential targets for dexamethasone intervention
of BPD.Conclusion We found the differential proteins related to the
sensitivity to glucocorticoids for BPD, which will provide the direction
for the choice of glucocorticoids in the treatment of BPD .