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Animal Models for SARS-CoV-2 research: Systematic Review of Literature and Future Directions
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  • Kabita Pandey,
  • Arpan Acharya,
  • Mahesh Mohan,
  • Caroline Ng,
  • Patrick Reid,
  • Siddappa Byrareddy
Kabita Pandey
University of Nebraska Medical Center
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Arpan Acharya
University of Nebraska Medical Center
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Mahesh Mohan
Texas Biomedical Research Institute
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Caroline Ng
University of Nebraska Medical Center
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Patrick Reid
University of Nebraska Medical Center
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Siddappa Byrareddy
University of Nebraska Medical Center Department of Pharmacology and Experimental Neuroscience
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Abstract

Emerging and reemerging viral diseases can lead to devastating effects on human lives and at times also lead to economic crises. The ongoing COVID-19 pandemic due to the novel coronavirus (nCoV), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which originated in Wuhan, China, has caused a global public health emergency. Still, the molecular mechanism of transmission of SARS-CoV-2, its clinical manifestations and pathogenesis is not completely understood. The global scientific community has intensified their efforts to understand the biology of SARS-CoV-2 to develop vaccines and therapeutic interventions to prevent the rapid spread of the virus and to control mortality and morbidity associated with COVID-19. To understand the pathophysiology of SARS-CoV-2, appropriate animal models that mimic the biology of human SARS-COV-2 infection is urgently needed. In this review, we outline animal models that have been used to study previous human coronaviruses (HCoVs), that includes severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV). Importantly, we discuss which model is appropriate for SARS-CoV-2 as well as the advantages and disadvantages of each.

Peer review status:IN REVISION

19 Jun 2020Submitted to Transboundary and Emerging Diseases
22 Jun 2020Assigned to Editor
22 Jun 2020Submission Checks Completed
23 Jun 2020Reviewer(s) Assigned
15 Jul 2020Review(s) Completed, Editorial Evaluation Pending
15 Aug 2020Editorial Decision: Revise Major