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Identifying the predictors of estimated glomerular filtration rate after partial nephrectomy with a nonlinear regression model
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  • Emre Karabay,
  • Cagatay Tosun,
  • Nejdet Karsiyakali,
  • Kemal Kayar,
  • Serdar Aykan,
  • Ahmet Ruknettin Aslan,
  • Omer Ergin Yucebas,
  • Metin Ishak Ozturk
Emre Karabay
Istanbul Haydarpasa Numune Egitim ve Arastirma Hastanesi
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Cagatay Tosun
İstanbul Haydarpaşa Numune Eğitim ve Araştırma Hastanesi
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Nejdet Karsiyakali
Acibadem Universitesi
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Kemal Kayar
İstanbul Haydarpaşa Numune Eğitim ve Araştırma Hastanesi
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Serdar Aykan
İstanbul Haydarpaşa Numune Eğitim ve Araştırma Hastanesi
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Ahmet Ruknettin Aslan
İstanbul Haydarpaşa Numune Eğitim ve Araştırma Hastanesi
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Omer Ergin Yucebas
İstanbul Haydarpaşa Numune Eğitim ve Araştırma Hastanesi
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Metin Ishak Ozturk
İstanbul Haydarpaşa Numune Eğitim ve Araştırma Hastanesi
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Abstract

Purpose: To evaluate the effect of partial nephrectomy on renal function and to identify predictors of estimated glomerular filtration rate (eGFR) at six months after partial nephrectomy. Methods: Medical data of 154 consecutive patients who underwent partial nephrectomy for a renal mass between January 2015 and March 2020 were retrospectively analyzed. The primary outcome measure was eGFR at six months postoperatively. A non-linear regression analysis was performed to examine the association between primary outcome measure and candidate predictors. Results: Of the patients, 66 (42.9%) were females and 88 (57.1%) were males with a median age of 60 (range, 50 to 67) years. The median baseline eGFR was 90.40 (range, 74.96 to 102.97) mL/min/1.73 m2, while the median eGFR at six months was 77.12 (range, 61.06 to 91.93) mL/min/1.73 m2 (p<0.001). Baseline eGFR (=22.691, 95%CI: 18.821 to 26.460, when baseline eGFR levels change from 74.97 ml/min/1.73 m2 to 102.68 ml/min/1.73 m2, p<0.001) was found to be directly associated with the postoperative eGFR levels at six months. In contrary, advanced tumor size (=-3.168, 95%CI: -5.332 to -1.005, when tumor size levels change from 3 to 6 cm, p<0.001) and presence of hypertension ( = -3.479, 95%CI: -6.956 to -0.0031, p=0.049) were also found to be inversely associated with the postoperative eGFR levels at six months. Conclusion: Baseline eGFR values, tumor size, and presence of hypertension are significant predictors of eGFR values in the mid-term in patients undergoing partial nephrectomy.

Peer review status:UNDER REVIEW

19 Jun 2020Submitted to International Journal of Clinical Practice
20 Jun 2020Submission Checks Completed
20 Jun 2020Assigned to Editor
25 Jun 2020Reviewer(s) Assigned
29 Aug 2020Review(s) Completed, Editorial Evaluation Pending
11 Sep 20201st Revision Received
12 Sep 2020Submission Checks Completed
12 Sep 2020Assigned to Editor
12 Sep 2020Reviewer(s) Assigned
22 Sep 2020Review(s) Completed, Editorial Evaluation Pending