loading page

Clinical and Laboratory Findings in COVID-19 Patients: Comparison of RT-PCR Positive and Negative Cases
  • +8
  • Farnaz karimi,
  • Amir Vaezi,
  • Mostafa Qorbani,
  • Fatemeh Moghadasi,
  • Saeed Hasani Gelsefid,
  • Arman Maghoul,
  • Neda Mahmoodi,
  • Zahra Eskandari,
  • Hossein Gholami,
  • Zakiye Mokhames ,
  • Mahshid Saleh
Farnaz karimi
Alborz University of Medical Sciences
Author Profile
Amir Vaezi
Alborz University of Medical Sciences
Author Profile
Mostafa Qorbani
Alborz University of Medical Sciences
Author Profile
Fatemeh Moghadasi
Alborz University of Medical Sciences
Author Profile
Saeed Hasani Gelsefid
Alborz University of Medical Sciences
Author Profile
Arman Maghoul
Alborz University of Medical Sciences
Author Profile
Neda Mahmoodi
Alborz University of Medical Sciences
Author Profile
Zahra Eskandari
Shahid Beheshti University of Medical Sciences
Author Profile
Hossein Gholami
Alborz University of Medical Sciences
Author Profile
Zakiye Mokhames
Alborz University of Medical Sciences
Author Profile
Mahshid Saleh
Author Profile

Abstract

The novel coronavirus disease 2019 (COVID-19) has turned into a global public health emergency after the first patients were detected in Wuhan, China, in December 2019. Methods This case-control study was conducted in two hospitals of Alborz Province in Iran. All symptomatic adults hospitalized as COVID-19 patients with compatible CT scan findings and available RT-PCR results were recruited in this study. The patients were categorized in positive and negative RT-PCR groups and evaluated for symptoms, initial vital signs, comorbidity, clinical and laboratory findings and the results were assessed by SPSS software. Results Between March 5 to April 5, 2020, 164 symptomatic COVID-19 patients were studied. In total, there were 111 RT-PCR positive (67.6%) and 53 RT-PCR negative patients (32.4%). In terms of statistics, the frequency of symptoms revealed no difference, except for cough (P.V:0.008), dizziness (P.V: 0.048) and weakness (P.V:0.022). Among initial vital signs, PR (P.V:0.041) and O2 Saturation (P.V: 0.014) were statistically different between the two groups. Evaluation of comorbidities revealed no difference except for hyperlipidemia (P.V:0.024). In comparison of laboratory findings, only WBC count (P.V: 0.001), lymphocyte count (P.V: 0.001) and Hb (P.V:0.008) were statistically different between the two groups. Conclusion In case of negative RT-PCR result, it is necessary to take a logical approach, and we recommended that the physician decide according to clinical manifestations, laboratory findings, and positive CT result