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Clinical and Laboratory Findings in COVID-19 Patients: Comparison of RT-PCR Positive and Negative Cases
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  • Farnaz karimi,
  • Amir Vaezi,
  • Mostafa Qorbani,
  • Fatemeh Moghadasi,
  • Saeed Hasani Gelsefid,
  • Arman Maghoul,
  • Neda Mahmoodi,
  • Zahra Eskandari,
  • Hossein Gholami,
  • Zakiye Mokhames ,
  • Mahshid Saleh
Farnaz karimi
Alborz University of Medical Sciences

Corresponding Author:[email protected]

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Amir Vaezi
Alborz University of Medical Sciences
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Mostafa Qorbani
Alborz University of Medical Sciences
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Fatemeh Moghadasi
Alborz University of Medical Sciences
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Saeed Hasani Gelsefid
Alborz University of Medical Sciences
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Arman Maghoul
Alborz University of Medical Sciences
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Neda Mahmoodi
Alborz University of Medical Sciences
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Zahra Eskandari
Shahid Beheshti University of Medical Sciences
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Hossein Gholami
Alborz University of Medical Sciences
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Zakiye Mokhames
Alborz University of Medical Sciences
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Mahshid Saleh
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Abstract

The novel coronavirus disease 2019 (COVID-19) has turned into a global public health emergency after the first patients were detected in Wuhan, China, in December 2019. Methods This case-control study was conducted in two hospitals of Alborz Province in Iran. All symptomatic adults hospitalized as COVID-19 patients with compatible CT scan findings and available RT-PCR results were recruited in this study. The patients were categorized in positive and negative RT-PCR groups and evaluated for symptoms, initial vital signs, comorbidity, clinical and laboratory findings and the results were assessed by SPSS software. Results Between March 5 to April 5, 2020, 164 symptomatic COVID-19 patients were studied. In total, there were 111 RT-PCR positive (67.6%) and 53 RT-PCR negative patients (32.4%). In terms of statistics, the frequency of symptoms revealed no difference, except for cough (P.V:0.008), dizziness (P.V: 0.048) and weakness (P.V:0.022). Among initial vital signs, PR (P.V:0.041) and O2 Saturation (P.V: 0.014) were statistically different between the two groups. Evaluation of comorbidities revealed no difference except for hyperlipidemia (P.V:0.024). In comparison of laboratory findings, only WBC count (P.V: 0.001), lymphocyte count (P.V: 0.001) and Hb (P.V:0.008) were statistically different between the two groups. Conclusion In case of negative RT-PCR result, it is necessary to take a logical approach, and we recommended that the physician decide according to clinical manifestations, laboratory findings, and positive CT result