Background and Aim: Acute gastrointestinal system (A-GIS) hemorrhages are frequent. Anemia is frequently seen in these patients at the discharge from the hospital. The anemia prevalence and approach to the anemia in patients with A-GIS bleeding at the time of discharge and during 3 months’ follow-up has been evaluated in this study. Method: In this study 197 patients diagnosed A-GIS bleeding in our hospital between January 2017 –May 2018 have been evaluated retrospectively. Results: In 129 of these patients upper gastrointestinal endoscopy, in 3 of them enteroscopy, in 45 of them lower gastrointestinal endoscopy, in 8 of them both upper and lower gastrointestinal endoscopy, in 2 of them upper, middle and lower gastrointestinal endoscopies were applied and 10 patients didnt performed endoscopy. In 69 of these patients therapeutic endoscopic treatments were applied. The mean of the length of hospitalization was 10±13.84 day and 67% of patients had erythrocyte transfusion with a mean value of 3.5±5.89 units during hospitalization. The mean of hemoglobin rate was 9.85±1.67 g/dL at the time of discharge from the hospital. In 92.4 % of the patients (F 91.1%, M 93.2%; upper GI bleeding 93.9%, middle GI bleeding 100%, lower GI bleeding 86.8%) anemia was detected at the time of the discharge. In 9.7% of these patients, iron deficiency treatment were applied. 33% of all 197 patients were evaluated 3 months after discharge from the hospital and in 80 % of these patients had still ongoing anemia. Conclusion: Anemia frequency is high when the patients with A-GIS bleeding are discharged. Most patients are discharged without receiving a prescription for the anemia. In follow-up, control applications are inadequate and anemia persists in patients