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Discussion about clinical value of detection of IL-10, IL-1β, IL-6, MCP-1, TNF-α, IP-10 and IL-4 for the diagnosis of COVID-19
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  • Qingqing Lu,
  • Zhenhua Zhu,
  • Hui Zhou,
  • Yan Hu,
  • Ge Shen,
  • Pan Zhu,
  • Gang Yang,
  • Xiaobing Xie
Qingqing Lu
Hunan University of Chinese Medicine
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Zhenhua Zhu
The First Hospital of Hunan University of Chinese Medicine
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Hui Zhou
The First Hospital of Hunan University of Chinese Medicine
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Yan Hu
The First Hospital of Hunan University of Chinese Medicine
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Ge Shen
Loudi Center for Disease Control and Prevention
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Pan Zhu
Loudi Center for Disease Control and Prevention
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Gang Yang
Loudi Center for Disease Control and Prevention
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Xiaobing Xie
The First Hospital of Hunan University of Chinese Medicine
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Abstract

Background and purpose: Studies have shown that some cytokines of COVID-19 were elevated. This study aims to assess whether IL-10, IL-1β, IL-6, MCP-1, TNF-α, IP-10 and IL-4 serve as diagnostic biomarkers of COVID-19 and offer prognostic insight upon initial presentation to help guide treatment,In addition, the relationships between them and gender, age, antibody concentration and course of disease were also discussed. Methods: The serum levels of cytokines above in experience group (COVID-19 patients) and control group (other diseases patients and healthy people) were detected by ELISA. Results: Most of the serum level of cytokines above in experience group were significantly higher than those in control group, and AUCs of COVID-19 diagnosed by they were 0.735, 0.775, 0.595, 0.821, 0.848, 0.387 and 0.987. The serum levels of some cytokines in male patients had noticeably higher than those in female patients, while the serum levels of almost all cytokines of the elderly were higher than that of the youth and middle-aged patients. The serum levels of IP-10 in patients were positively correlated with IgM, while TNF-α were negatively correlated with IgG. The levels of IL-1 β and IL-6 increased sharply in the early stage of COVID-19, then decreased gradually; the levels of IL-10, MCP-1, TNF-α and IL-4 increased sharply in the middle stage, while the levels of IP-10 increased sharply in the late stage. Conclusion: The cytokines above can prove to be great significance for clinical diagnostics of COVID-19, and the levels of cytokines in patients have some relationships with gender, age and course of disease.

Peer review status:ACCEPTED

28 Jun 2020Submitted to International Journal of Clinical Practice
01 Jul 2020Submission Checks Completed
01 Jul 2020Assigned to Editor
28 Jul 2020Reviewer(s) Assigned
17 Nov 2020Review(s) Completed, Editorial Evaluation Pending
03 Dec 20201st Revision Received
08 Dec 2020Submission Checks Completed
08 Dec 2020Assigned to Editor
08 Dec 2020Reviewer(s) Assigned
17 Jan 2021Review(s) Completed, Editorial Evaluation Pending
18 Jan 20212nd Revision Received
21 Jan 2021Assigned to Editor
21 Jan 2021Submission Checks Completed
21 Jan 2021Reviewer(s) Assigned
11 Feb 2021Review(s) Completed, Editorial Evaluation Pending
17 Feb 20213rd Revision Received
17 Feb 2021Submission Checks Completed
17 Feb 2021Assigned to Editor
19 Feb 2021Reviewer(s) Assigned
24 Feb 2021Review(s) Completed, Editorial Evaluation Pending
20 Mar 20214th Revision Received
20 Mar 2021Assigned to Editor
20 Mar 2021Submission Checks Completed
10 Apr 2021Reviewer(s) Assigned
25 Apr 2021Review(s) Completed, Editorial Evaluation Pending
08 May 20215th Revision Received
08 May 2021Assigned to Editor
08 May 2021Submission Checks Completed
08 May 2021Review(s) Completed, Editorial Evaluation Pending
24 May 2021Editorial Decision: Accept