Dehydroepiandrosterone(DHEA) combining Metformin – Adjuvant Agents for
Ovulation Induction in Poor Ovarian Responders
Objective: To investigate the impact of Dehydroepiandrosterone(DHEA)
combining Metformin on IVF-ET outcomes in poor ovarian responders(PORs).
Materials and Methods: This is a retrospective cohort study. There were
237 women undergoing IVF-ET cycles. A total of 106 cycles met the
Bologna criteria (44.8%) as poor responders in this study period. They
were divided into two groups according to with or without
supplementation. Results: The number of oocytes retrieved (3.5±2.5 vs.
1.5±0.8, p = 0.027), the clinical pregnancy rate(21.7 vs. 11.5, p =
0.008) and the live birth rate(16.7 vs. 8.7, p = 0.007) were
significantly higher in the group with supplementation than in the group
without. Conclusion: The adjuvant agents: DHEA and Metformin for
ovulation induction seemed to improve the number of oocytes retrieved,
clinical pregnancy rate and live birth rates in poor ovarian responders.