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Overlapping tumor-specific expression of p53, p16INK4a , and sirtuin 1 in Bowen’s Disease: A Case Report
  • Tomoaki Takada
Tomoaki Takada
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Abstract

The tumor of a patient with Bowen’s disease exhibited expression of the tumor suppressors p53 and p16INK4a(p16), which correlated with cytoplasmic expression of the histone deacetylase sirtuin 1(SIRT1). Epigenetic regulation of p53 and p16 by SIRT1 may play a role in the carcinogenesis of Bowen’s disease.

Peer review status:ACCEPTED

29 Jun 2020Submitted to Clinical Case Reports
01 Jul 2020Submission Checks Completed
01 Jul 2020Assigned to Editor
19 Jul 2020Reviewer(s) Assigned
19 Aug 2020Review(s) Completed, Editorial Evaluation Pending
15 Sep 20201st Revision Received
16 Sep 2020Submission Checks Completed
16 Sep 2020Assigned to Editor
16 Sep 2020Review(s) Completed, Editorial Evaluation Pending
19 Sep 2020Editorial Decision: Accept